John Le Quesne Selected Research

Colorectal Neoplasms (Colorectal Cancer)

1/2023	Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer.
1/2021	MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.

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John Le Quesne Research Topics

Disease

20	Neoplasms (Cancer) 01/2023 - 01/2012
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2021 - 07/2014
4	Malignant Mesothelioma 01/2023 - 01/2018
4	Adenocarcinoma of Lung 01/2022 - 12/2019
3	Neoplasm Metastasis (Metastasis) 07/2021 - 01/2021
3	Breast Neoplasms (Breast Cancer) 01/2020 - 11/2009
3	Lung Neoplasms (Lung Cancer) 12/2019 - 07/2014
2	Inflammation (Inflammations) 01/2023 - 01/2019
2	Colorectal Neoplasms (Colorectal Cancer) 01/2023 - 01/2021
2	Mesothelioma 01/2023 - 11/2017
2	Necrosis 01/2023 - 01/2018
2	Adenoma (Adenomas) 01/2022 - 12/2019
2	Adenocarcinoma 01/2022 - 12/2019
2	Carcinogenesis 01/2021 - 11/2017
2	Disease Progression 12/2019 - 11/2017
1	Tertiary Lymphoid Structures 01/2023
1	Asthma (Bronchial Asthma) 11/2022
1	Acute Disease 11/2022
1	Heart Failure 11/2022
1	Cytokine Release Syndrome 01/2020
1	COVID-19 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2020
1	Triple Negative Breast Neoplasms 01/2020
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2018

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2013
5	Biomarkers (Surrogate Marker)IBA 11/2022 - 09/2016
3	AsbestosIBA 01/2023 - 11/2017
2	RNA (Ribonucleic Acid)IBA 01/2023 - 01/2020
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022 - 04/2020
2	DNA (Deoxyribonucleic Acid)IBA 12/2019 - 01/2017
1	Amosite Asbestos (Amosite)IBA 01/2023
1	Cre recombinaseIBA 01/2023
1	Calcium-Binding ProteinsIBA 01/2023
1	Circulating Tumor DNAIBA 01/2023
1	HydrocarbonsIBA 11/2022
1	Volatile Organic CompoundsIBA 11/2022
1	AldehydesIBA 11/2022
1	Atorvastatin (Lipitor)FDA Link 01/2022
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2021
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2021
1	CollagenIBA 01/2021
1	5'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA 01/2021
1	Dual Specificity Phosphatase 6IBA 01/2021
1	MTOR InhibitorsIBA 01/2021
1	SOX9 Transcription FactorIBA 01/2021
1	Eukaryotic Initiation Factor-4EIBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	130-nm albumin-bound paclitaxelIBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	Immune Checkpoint InhibitorsIBA 01/2020
1	Interleukin-1 (Interleukin 1)IBA 01/2020
1	InterleukinsIBA 01/2020
1	atezolizumabIBA 01/2020
1	Cell-Free Nucleic AcidsIBA 12/2019
1	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 01/2019
1	VimentinIBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2018
1	LigandsIBA 01/2018
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018
1	Death Domain ReceptorsIBA 01/2018
1	Deubiquitinating EnzymesIBA 01/2018
1	tyrosine receptor (receptor, tyrosine)IBA 01/2018
1	Messenger RNA (mRNA)IBA 01/2018
1	Carbon Fiber (Grafil)IBA 11/2017
1	Cyclin-Dependent Kinase Inhibitor p16IBA 11/2017
1	ChromatinIBA 01/2017
1	CrizotinibIBA 06/2014
1	3' Untranslated Regions (3' UTR)IBA 06/2013
1	thiamine triphosphorate (TTP)IBA 06/2013
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2012
1	ClaudinsIBA 01/2012
1	MicroRNAs (MicroRNA)IBA 11/2009

Therapy/Procedure

10	Therapeutics 01/2021 - 07/2014
2	Adjuvant Chemotherapy 05/2021 - 01/2017
1	Euthanasia (Mercy Killing) 01/2023
1	Immunotherapy 01/2023
1	Prostatectomy (Retropubic Prostatectomy) 07/2021
1	Drug Therapy (Chemotherapy) 01/2018
1	Precision Medicine 07/2014